EDUCATION
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2011 |
PhD in Neuroscience, University College London, London, United Kingdom
PhD Supervisor: Prof. Michael Häusser |
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2006 |
Diploma in Human Biology, Philipps-University of Marburg, Marburg, Germany |
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2000 |
Abitur, Klosterschule Rossleben, Germany |
PROFESSIONAL APPOINTMENTS
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Current Positions |
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10/2020-now |
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany, Research Group Leader (tenured, W3) |
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7/2024-now |
University of Bonn, Medical Faculty, University Professor (W3, Jülicher Modell)
Previous Positions |
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Previous Position |
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2018-2021 |
SNF Professor, University of Basel, Department of Biomedicine, Basel, Switzerland |
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2015-2017 |
Ambizione Fellow, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland |
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06-09/2013 |
Visiting Scholar, Stanford University, Laboratory of Prof. Mark Schnitzer, Stanford, USA |
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2011-2014 |
Postdoctoral Fellow (EMBO LTF) Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland |
ACTIVITIES IN THE ACADEMIC SYSTEM
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Speaker: DZNE Neuronal Networks Program (www.dzne.de/neuronal-networks)
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Co-Speaker: DZNE Helmholtz POF Scientific Evaluation. Topic 1 ‘Brain Function’ (2025)
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Co-organizer: 7th Bonn Brain³ Conference, Bonn, Germany (2024)
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Organizer: Cold Spring Harbor Course: Ion Channel Physiology (2019-23)
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Joint Hiring-Committees DZNE & University of Bonn, Medical Faculty
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IMPRS for Brain and Behavior (Faculty), Bonn, Germany
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BIGS Neuroscience Graduate School (Faculty), Bonn, Germany
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iBehave Technology Steering Committee, NRW, Germany
FELLOWSHIPS & PRIZES
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2020 |
Forschungspreis der Schweizerischen Hirnliga (shared with Andreas Lüthi) |
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2018 |
ERC starting grant, European Research Council |
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2017 |
SNF Professorship, Swiss National Science Foundation |
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2017 |
Wellcome Trust Sir Henry Dale Fellowship (awarded, not taken) |
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2016 |
King’s College London Prize Fellowship (awarded, not taken) |
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2014 |
Ambizione Fellowship, Swiss National Science Foundation |
RESEARCH FOCUS
The reliable integration of an ever-changing multitude of environmental inputs is fundamental for learning, memory, and behaviour. Our research aims to understand how information from the world is represented, integrated, and transformed within neuronal networks to uncover key principles of computation underlying memory formation in a state-dependent manner, including during learning, consolidation, and sleep. To achieve this, we combine state-of-the-art circuit neuroscience tools such as opto- and pharmacogenetics with single- and two-photon imaging, miniaturized microscopy for deep-brain recordings, light-sheet microscopy, and advanced AI-driven analysis to reveal frameworks of neuronal coding and plasticity. Our work furthermore focusses on mechanisms of structural plasticity including changes in axonal function, with the common goal of elucidating how these processes support memory formation and recall in the healthy brain, and how they break down in the context of disease.
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SELECTED PUBLICATIONS
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Benoit CM, Ganea DA, Thome C, Sattin A, Innocenti SM, Krabbe S, Lüthi A, Fellin T, Engelhardt M, Gründemann J.
Axon initial segment dynamics during associative fear learning.
Nature Neurosci. 2026 29(3):535-542. https://doi.org/10.1038/s41593-025-02152-5
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Paricio-Montesinos R, Gründemann J
Sensory thalamus function, plasticity and neuromodulation in health and disease.
Brain Res Bull. 2025 230:111508. https://doi.org/10.1016/j.brainresbull.2025.111508
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Hasegawa M, Huang Z, Paricio-Montesinos R, Gründemann J
Network state changes in sensory thalamus represent learned outcomes.
Nature Comm. 2024; 15(1):7830. https://doi.org/10.1038/s41467-024-51868-8
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d’Aquin S, Szonyi A, Mahn M, Krabbe S, Gründemann J, Lüthi A
Compartmentalized dendritic plasticity during associative learning.
Science. 2022 Apr 15; 376(6590):eabf7052. https://doi.org/10.1126/science.abf7052
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Taylor JA, Hasegawa M, Benoit MC, Freire JA, Theodore M, Ganea DA, Innocenti SM, Lu T, Gründemann J
Single cell plasticity and population coding stability in auditory thalamus upon associative learning
Nature Comm. 2021 2438:1-9. https://doi.org/10.1038/s41467-021-22421-8
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Gründemann J
Distributed coding in auditory thalamus and basolateral amygdala upon associative fear learning.
Curr Opin Neurobiol. 2021 Apr; 67:183-189. https://doi.org/10.1016/j.conb.2020.11.014
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Gründemann J, Bitterman Y, Lu T, Krabbe T, Grewe BF, Schnitzer MJ, Lüthi A
Amygdala ensembles encode behavioral states.
Science. 2019 Apr 19; 364(6437). pii: eaav8736. https://doi.org/10.1126/science.aav8736
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Grewe BF, Gründemann J, Kitch LJ, Lecoq JA, Parker JG, Marshall JD, Larkin MC, Jercog PE, Grenier F, Li JZ, Lüthi A, Schnitzer MJ.
Neural ensemble dynamics underlying a long-term associative memory.
Nature. 2017 Mar 30; 543(7647):670-675. doi: 10.1038/nature21682.
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Gründemann J, Clark BA.
Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.
Cell Rep. 2015 Sep 22; 12(11):1715-22. doi: 10.1016/j.celrep.2015.08.022.
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Wolff SB, Gründemann J, Tovote P, Krabbe S, Jacobson GA, Müller C, Herry C, Ehrlich I, Friedrich RW, Letzkus JJ, Lüthi A.
Amygdala interneuron subtypes control fear learning through disinhibition.
Nature. 2014 May 22; 509(7501):453-8. doi: 10.1038/nature13258.
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