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Wir fördern Neurowissenschaften in Forschung und Lehre und unterstützen den wissenschaftlichen Nachwuchs.

Prof. Dr. Matthias Kneussel

Prof. Dr. Matthias Kneussel

Sektionssprecher "Molekulare Neurobiologie"

Dept. of Molecular Neurogenetics, ZMNH
University Medical Center Hamburg-Eppendorf
Martinistr. 52
20246 Hamburg

Tel.: 040-7410-56275

E-Mail: matthias.kneussel@zmnh.uni-hamburg.de

Curriculum Vitae

Date of birth    23 January 1966
Children Married, three children

Academic education

10/1987-12/1992 Studies of Biology (Diploma), Technical University, Darmstadt.
01/1993-10/1993     Diploma work at Max-Planck Institute for Biophysics, Frankfurt/Main with Prof. Dr. H. Passow

Academic degrees

7/1997 Ph.D. defence (Dr. rer. nat.) at Technical University, Darmstadt
01/1994-07/1997   Ph.D. at University College, UCL, London, UK with Prof. Dr. D. Colquhoun/Prof. Dr. R. Schoepfer

                   

Professional experience

1/2010-present Full Professor of Neuroscience (W3), Director of the Institute for Molecular Neurogenetics, ZMNH, UKE, University of Hamburg
08/2002-01/2010 Independent Research Group Leader, Center for Molecular Neurobiology, Hamburg, ZMNH, UKE, Universit of Hamburg
10/1999-07/2002 Research Group Leader, Neurotransmitter receptor group, Dept. of Neurochemistry, Max Planck Institute for Brain Research Frankfurt/Main with Prof. H. Betz
10/1997-09/1999 Postdoc at Max-Planck Institute for Brain Research, Frankfurt/Main with Prof. Dr. H. Betz
07/1997-10/1997 Postdoc at University College, UCL, London, UK with Prof. Dr. D. Colquhoun/Prof. Dr. R. Schoepfer

    

Awards and other academic functions

2016 Speaker of the DFG Research Unit FOR2416 “Plasticity versus Stability - Molecular Mechanisms of Synaptic Strength”
2010-2014 Co-speaker of the DFG Research Unit FG885 “Neuronal Protein Turnover”, UKE, Universities of Hamburg and Cologne
2009-present Review Editor at Frontiers of Molecular Neuroscience
2006                             Research Award of the Chica and Heinz Schaller Foundation, University of Heidelberg
2005 Habilitation in Molecular Biology and Genetics, University of Hamburg
2004 Habilitation in Biochemistry, University of Frankfurt/Main
2001 Young Investigator Award of the German Neuroscience Society, NWG

Scientific Focus

Hauptfokus meiner Arbeit ist die Dynamik und Zielsteuerung synaptischer Proteine und deren Bedeutung für synaptische Plastizität, Lernen und Gedächtnis. Wir untersuchen molekulare Prozesse die synaptische Funktion stärken oder abschwächen, sowie die Struktur von Synapsen verändern. Ein Schwerpunkt unserer Arbeit liegt hierbei auf Motorproteinen, die molekulare Transportprozesse entlang des Mikrotubuli- und Aktin-Zytoskeletts vermitteln und steuern. Wir möchten verstehen welche Rolle neuronale Aktivität für die Sortierung und den Transport synaptischer Proteine spielt. Neben molekularen Techniken und Lebendzellmikrokopie untersuchen wir genetisch veränderte Mausmodelle in Verhaltensexperimenten.

Selected Publications

  • Kneussel M, Triller A, Choquet D (2014) SnapShot: receptor dynamics at plastic synapses. Cell 157:1738-1738.e1
  • Heisler FF, Lee HK, Gromova KV, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M (2014) GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites. PNAS 111:5030-5035.
  • Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob T, Moss S, Benfenati F, Medini P, Kneussel M, and Barberis A (2014) Synaptic recruitment of gephyrin regulates surface GABAA receptors dynamics for the expression of inhibitory LTP. Nature Communications 5: 3921.
  •  Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Bruck W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA (2012) TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Medicine 18:1805-1811.
  • Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovich AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur EL, Schmitz D, Kneussel M (2011) Muskelin regulates actin filament- and microtubule-based GABA-AR transport in neurons. Neuron 70: 66-81
  • Maas C, Belgardt D, Lee HK, Heisler FF, Lappe-Siefke C, Magiera MM, van Dijk J, HausratTJ, Janke C, Kneussel M (2009) Synaptic activation modifies microtubules underlying transport of postsynaptic cargo. PNAS 106: 8731-8736
  • Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T. Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. Neuron. 2016 Oct 18. pii: S0896-6273(16)30654-7. doi: 10.1016/j.neuron.2016.09.049. [Epub ahead of print] PubMed PMID: 27773584.
  • Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J. Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. Neuron. 2016 Oct 5;92(1):126-142. doi: 10.1016/j.neuron.2016.08.035. PubMed PMID: 27641493; PubMed Central PMCID: PMC5065528.
  • Muhia M, Thies E, Labonté D, Ghiretti AE, Gromova KV, Xompero F, Lappe-Siefke C, Hermans-Borgmeyer I, Kuhl D, Schweizer M, Ohana O, Schwarz JR, Holzbaur EL, Kneussel M. The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory. Cell Reports 2016 May 3;15(5):968-77. doi: 10.1016/j.celrep.2016.03.086. PubMed PMID: 27117409.
  •  Kneussel M, Hausrat TJ. Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation. Trends in Neurosciences 2016 Mar;39(3):170-82. doi: 10.1016/j.tins.2016.01.002. Review. PubMed PMID: 26833258.
  • Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M. Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Nature Communications 2015 Apr 20;6:6872. doi: 10.1038/ncomms7872. PubMed PMID: 25891999; PubMed Central PMCID: PMC4411296